Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach
نویسندگان
چکیده
منابع مشابه
Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with supportive and symptomatic management. The antibody works extracellularly, probably by blocking the binding of receptor binding (R) domain to the...
متن کاملBotulinum Neurotoxins
Botulism is a neuroparalytic disease caused by neurotoxin produced from the bacterium Clostridium botulinum. The botulinum neurotoxins (BoNTs) are among the most potent known biological toxins and have an estimated human median lethal dose (LD50) in the nanogram/kilogram range. Botulinum toxins have historically been employed as biological weapons (BW) through state-sponsored programs in Japan,...
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OBJECTIVE The aim of this article is to review the mechanism of action, physiological effects, and therapeutic applications of botulinum neurotoxins in the head and neck area. STUDY DESIGN An extensive literature search was performed using keywords. The resulting articles were analyzed for relevance in four areas: overview on botulinum neurotoxins, the role of botulinum neurotoxins in the man...
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Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors targeting common steps of their intoxication process. Recently, EGA was shown to inhibit the action of bacterial toxins and viruses exhibiting a pH-dependent translocation step in mammalian cells, by interfering with their entr...
متن کاملZebrafish Sensitivity to Botulinum Neurotoxins.
Botulinum neurotoxins (BoNT) are the most potent known toxins. The mouse LD50 assay is the gold standard for testing BoNT potency, but is not sensitive enough to detect the extremely low levels of neurotoxin that may be present in the serum of sensitive animal species that are showing the effects of BoNT toxicity, such as channel catfish affected by visceral toxicosis of catfish. Since zebrafis...
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ژورنال
عنوان ژورنال: Toxins
سال: 2011
ISSN: 2072-6651
DOI: 10.3390/toxins3050469